On the Bridge: A Conversation Between a Pro-Lifer and an Embryonic Stem Cell Researcher @TheHuffingtonPost

hESCs@CHOC

When I investigated human embryonic stem cell (hESC) research for Christianity Today in 2005, the debate about the ethics of the science was heated and tense. I was a pro-lifer who’s child had an incurable disease. What I wanted to know was: what would I do if hESCs could cure my child’s Neurofibromatosis? As part of that investigation, I spent ten days attending a National Institutes of Health (NIH) training course for post-doctoral scientists at Children’s Hospital of Orange County (CHOC) in Southern California. Every other attendee was there to learn how to create and grow stem cell lines from five day old human embryos (blastocysts). Because it was an NIH funded course, no new embryos were destroyed to grow the lines the researchers manipulated.

I was the invited guest of Phil Schwartz, who is both director of the Human Neural Stem Cell Resource at CHOC and a Christian opposed to embryo destruction. Schwartz ran the course with Jeanne Loring, director of the Center for Regenerative Medicine at The Scripps Research Institute in San Diego, California. Loring is a cell biologist who has been working with hESCs since 1997. Before that, she worked with another Christian, Francis Collins, on mapping the human genome. She describes herself as a “cultural Catholic,” but practices no religion and has never had any doubts about the ethics of her hESC work.

In 2008, Schwartz invited me to attend the course again and I did. The political tenor had changed considerably with the advent of induced pluripotent stem cells (iPSCs), which are derived from adult somatic cells and thus are not controversial.

Writing on the Center for Genetics and Society’s blog, Project Director on Biotechnology Accountability Jesse Reynolds predicted,

“With the end of stem cell research as a political vehicle, its advocates are likely to temper expectations. They’ll not just move out the goalposts on the timeline towards treatments, but the touted uses of stem cells will shift from potential cellular therapies to models of human diseases in Petri dishes and better drug testing methods. These new purposes will win fewer votes than ‘your own personal biological repair kit,’ but they are also much more realistic.”

And yet, here we are again, with advocates lamenting a lawsuit that brought a temporary injunction against NIH funding of hESC research. (The injunction was quickly reversed.) So, I called Jeanne Loring and asked her thoughts on the lawsuit and the current state of the field. Here’s that interview, edited for space:

SCHELLER: What do you think of the legal situation?

LORING: For scientists, the embryonic stem cells have been the basis for all of the research, including the induced pluripotent stem cell research. Also, they’ve had a lot of influence over adult stem cell research, although I don’t think those guys would admit it. … There’s a gradual growing excitement … because of what you can do with them. So we have people with all sorts of different skills that are all focusing on hESCs or iPSCs or stem cells in general. What the legislation does is it puts a halt to an awful lot of research that’s ongoing right now. Maybe in another ten years, it wouldn’t have such an impact because people would have already done all these things and it would all be in the hands of companies, but right now it’s in a really frantic research phase. We’re discovering things all the time. It’s the worst possible time to have money taken away.

SCHELLER: Who brought case?

LORING: A researcher who used to be at [Harvard] MIT. Harvard [MIT] denied him tenure and he went on a hunger strike. That’s what he was famous for. I knew I’d heard of him before.

SCHELLER: Was he opposed to the research on ethical grounds?

LORING: There are two people: a woman from Louisiana, I believe, opposing the research on ethical grounds and this guy. In legal terms, in order to get an injunction, you have to show financial harm. He said he was being financially damaged because hESC research was unfairly competing with adult stem cell research at NIH. It’s outrageous. It’s foolish. It’s silly. Because research funded by the NIH is funded on merit and there’s no one pot for all stem cell research that gets divided up differently. There’s a big pot for all sorts of research and depending on the stage of the science and the urgency of the need, the research dollars go in a lot of different directions. Adult stem cell research gets far more funding than embryonic stem cell research and it continues to, mostly because it’s already well established.

SCHELLER: Do you think the spinal cord hESC therapy human trials that have been approved by the FDA [the first of their kind] at the Reeve-Irvine research Center in Southern California will work?LORING: I don’t know. Scientifically, I think there’s a possibility. As a scientist, what I really want are for those cells to not harm anybody because it’s a Phase One trial and the object of a Phase One trial is to show that it doesn’t do any harm, and that will be a huge step forward if they can show that.

SCHELLER: In 2008, we heard from Geron Corporation funded Oxford scientist Paul Fairchild that the immune challenge with hESCs wouldn’t be overcome. Has that changed?

LORING: No. They are going to have an immune problem, but they’re going to treat it like an organ transplant. They’re going to use the minimum amount of immune suppression that they can get away with. … This is not a fix for immune rejection. I just got a grant to develop of way to trick the immune system into thinking transplanted cells are theirs. There are several projects going on along those lines. The cells themselves are not going to move into another body and not cause a reaction, which is actually good because if your immune system is not aware of something and that cell became cancerous, you couldn’t do anything about it.

SCHELLER: California Institute for Regenerative Medicine (CIRM) co-founder Robert Klein is the father of a diabetic child. I’ve never understood the trade off of insulin dependency for immune suppression that diabetic patients would potentially make if hESC therapies become available. Do you grapple with that at all?

LORING
: Sure. Ranking diseases is always difficult. A lot of what diseases are going to be treated with cell therapy really depends on a balance between how serious they are and how deadly they are and how easily they can be treated with cells. So, diabetes seems to be, relatively among all diseases, probably easier than most to treat, but it’s not life-threatening. So you have to get a really good therapy, but definitely require immune suppression before you would actually use it.

SCHELLER
: So there’s a benefit/risk analysis?

LORING: Yeah, that’s right. So there is progress to be made. All this immune system stuff is sort of catching fire now, so people are not going to just stand by and let the immune system reject everything. They’re going to try to modify the immune system, not with immune suppression, but in a way that will last. Now people are also encapsulating cells so that the immune system can’t get at them.

SCHELLER: They’re still able to function when they’re encapsulated?

LORING: Yeah, in diabetes they certainly are because all they have to do is react to glucose in the blood and make insulin.

SCHELLER: Last time I talked to you, you sounded more excited about iPSCs than hESCs.

LORING: I am more excited for a lot of reasons about iPSCs because you can make them from any individual. As far as the way they act in the culture dish, they’re exactly the same as embryonic stem cells. You have the same problems and the same advantages.

SCHELLER: Is it much harder to get them to turn into other cell types than it is with hESCs?

LORING
: No. It’s very easy to get them to turn into other cell types. They’re essentially equivalent. If you look at 100 iPSCs and 100 hESCs, you’ll find there are outliers in both groups–cells that are difficult or act funny. But on the average, among those 200 cell lines, you really couldn’t tell them apart.

SCHELLER: 2009 was the last NIH funded course you directed with Phil Schwartz. Is there no longer a need to train scientists?

LORING: My lab is still running courses. We’re doing it semi-independently and also for CIRM. They are more popular than ever. We modified them so we are actually offering them every couple of months because there are so many people in line waiting to take them.

SCHELLER: So it’s not the case then, as it was in 2005, that you have more cell lines than scientists to do the research?

LORING
: No, it’s not like that at all. People really want to get involved in this field. We still teach embryonic stem cell culture methods because that is still the fundamental technology that underlies all of this work.

SCHELLER: Do you need new hESC lines?

LORING: No, I don’t need to make hESCs. This is a dilemma. You make hESC lines from five-day old blastocystes that have been donated by people in in-vitro fertilization (IVF) clinics. I’ve been getting repeated frantic emails from people who want to donate their embryos. I don’t really have any need for them, but I’m feeling like I should start a bank. The alternative is throwing them away. Nobody’s going to adopt the embryos, so they’re paying to have them stay frozen and they want to see some good come of them. I want to start a bank. It’s just that I don’t have funding for it. I’m cooperating with an IVF physician who’s temporarily taking the embryos in. We definitely don’t need to make embryonic stem cell lines. There are probably 400 around now. All you have to do is call somebody and ask them for them.

SCHELLER: At the 2008 course, an IVF physician called his field “Cowboy Science” because of the lack of regulation. It seems to me that this lack of regulation may be a bigger ethical problem than hESC research because it creates the excess embryos.

LORING: I have no objection to increasing regulation of IVF. It’s like any medical practice. It shouldn’t be hurt by oversight.

SCHELLER: We also heard about the potential for exploitation of egg donors in 2008.

LORING: The egg donation issue in 2008 was very hot. That’s died out considerably with the advent of iPSCs because people were looking for alternative sources for pluripotent cells and now there is an alternative source.

SCHELLER: As you know, I first investigated this topic because my first pregnancy was unplanned and I didn’t believe I had the right to end it. My child was then born with Neurofibromatosis. So I had an ethical dilemma to think about when hESC research first emerged.

LORING: Yeah, I understand. I obviously don’t feel it in my heart, but I understand.

SCHELLER: How would you describe your ethical convictions about hESC research?

LORING: I find it completely ethical. I have absolutely no problems with it. It isn’t abortion, so my opinion about abortion is irrelevant. The fact that these embryos would be thrown away and not used for research, I think it would be unethical not to use them.

SCHELLER: You’ve never had any doubts?

LORING: I’ve never had a doubt.

SCHELLER: How long have you been doing this research?

LORING: I started in 1997 in northern California. I started my own company to make hESCs. I didn’t know then that there were so many embryos being thrown away every day. So it made me nervous to have embryos in the lab and I made sure that I got good cell lines out of them. It would still do that to me now. They are really precious, but if you can’t do anything else with them. I was interviewed by a reporter for a Christian newspaper maybe a year ago, I actually wanted to talk to this guy because I wanted to suggest that the churches should put up embryo banks because there’s no adoption for embryos. It would be like starting an orphanage. If they want to keep the embryos from being used for research or being thrown away, then they should set up a bank, a freezer somewhere and just keep them.

SCHELLER: And then do what with them?

LORING: Whatever they want.

SCHELLER: In other words, they should take responsibility for their convictions?

LORING: Exactly. Nobody took me up on it. I’m happy to say that again though.

SCHELLER: People say similar things to pro-life Christians about abortion.

LORING: This would be really simple, though, simple and cheap because you don’t have to raise them. All you have to do is keep them frozen. And then you can figure out what should happen to them after that. That’s not my problem.

SCHELLER: Do you get any flack from your Catholic relatives about your work?

LORING: No. As you know, many Catholics also think birth control is okay and a lot think IVF is fine. So it all follows from that. My relatives are pretty intelligent people, so I don’t get any trouble from them. There might be an outlier somewhere, but not a close relative.

SCHELLER: Thanks for talking to me Jeanne. I always appreciate the fact that you shed light rather than heat on this issue.

LORING: If somebody wants controversy, they’re going to have to go somewhere else.

Check out the reaction to this interview at The Huffington Post.

The Case for Male Circumcision @Her.meneutics

I really had no idea how passionate people could be about this topic until I tweeted my intent to respond to a BloggingHeads.tv discussion of it. Below is the intro to my allegedly man-hating take. Above is a photo of my two precious boys.

What mother hasn’t, in the halcyon days after the birth of a son, felt her ferocious she-wolf instincts kick in when it comes time for her boy to be circumcised? Having perhaps suffered violence to her genitals during the birth, the physical ache to all that is vulnerable in her world can seem unbearable. And then it is done, and life goes on.

Anti-circumcision activists would have us believe that life does not in fact go on, that boys grow into men whose sexual pleasure (and that of the women they love) is compromised by this act of “genital mutilation.” While increasing numbers are swayed by both argument and sentiment, I’m stupefied by the controversy.

Male sexual pleasure is not my highest priority, having rarely witnessed a lack thereof. Nor is my own, if in fact I’m speaking out of my ignorance of the delight foreskin can deliver. What I am concerned about is sky-rocketing rates of sexually transmitted diseases, and the gender inequality evident in these rates. …

Read the rest here. For a taste of the emotion this topic inspires, be sure to read the comments, and my response to them.

Update 9/14/09: I posted this definitive comment in response to the 90+ comments on my post, and will have nothing further to say on this topic for the time being.

I really appreciate all the insightful, civil comments on this post. I’m not going to respond to them or to the hostile ones, as I’ve said my piece and others have filled in the blanks.

What I would like to explain is that as a journalist, I look for an angle on a topic that has not been covered sufficiently elsewhere. In my research for this post, I noticed that the writers I was reading seemed to miss the comparison to women’s embodied experience, so I chose to highlight that comparison.

I always consider what I write a contribution to public conversation, not a definitive statement on any given topic. Thus, I am gratified that what I’ve written has spurred people to think about something they might not have otherwise considered. If readers disagree with me, fine. Let the conversation continue and lead to change where it might be necessary.

In regard to this particular issue, I confess a subtle bias that I did not reveal in the post. I trust the Bible as my primary source of authority and have a bias towards its commands and injunctions. For example, I suspect that a kosher diet is probably healthiest, even though I don’t keep kosher. When God told women to stay outside the camp during menstruation, I think of that as a mercy. In the case of circumcision, I tend to think that if God ordained it, there is something inherently beneficial in the act itself.

When Abraham was commanded to be circumcised, he was a grown man, and must have been as horrified as many of you. Family members who did not hear from God must have been even more horrified. (LL Barkat made this point to me privately.) Still, circumcision became the sign of faith. Even if there were no medical benefits that science would later suggest, there are other values demonstrated in the act: pleasure is not our highest end; we are to acknowledge God’s sovereignty over our most vulnerable, intimate issues and trust him with our whole selves; logic is not to be our final authority, etc.

Don’t misunderstand. As I’ve already stated, the apostles declared circumcision of the heart the true sign of faith, as was consistent with Jesus’ reforms. Our Lord affirmed the Law though, and so I respect it, even when I don’t entirely understand it or live it out or think we are subject to it. I simply have a bias towards it.

I confess that there is a superstitious element to my reasoning. I also confess that scientism is probably the bigger problem with all kinds of medical procedures. If postmodernism has done nothing else, it has given us back a willingness to own our instincts.

Which brings me back to our faithful reader, Christian Lawyer, who I chose to engage because she consistently makes good points.

This I agree with: “If you want to teach our young people that they are powerless in the face of the “culture,” have at it, but don’t be surprised when these same young people succumb to the buffeting winds of suggestion, peer pressure, and defeatism rather than learning to stand strong and take responsibility for themselves and the circumstances of their lives.

The paternalism of the far right complementarians, just like the maternalism of the the far left feminists, is disempowering to women and instead breeds weakness.”

However, I never said I was powerless. I said I was influenced. Because of public conversations like the ones we have here at Her.meneutics, the excesses of both feminism and FAR RIGHT complementarianism may weaken. I hope to advance those goals.

With this, I disagree:

“Advocating cutting off men’s foreskins to protect women, rather than advocating education and contraception for women so they can protect themselves, is just another creepy example of the disempowerment of women under the guise of ‘protection.'”

Not either/or, but both/and. I am grateful that my mother took me to a gynecologist for contraception when she knew I was having sex and had no intention of stopping. However, this doctor (like the one who performed my tubal ligation) doled out treatment without asking a single penetrating question. I think this was a combination of both sexism and scientism.

Finally, I am no longer going to respond to anyone who does not own their comments with their full name and/or a link to their website or blog. I own my public comments both here and elsewhere. When I comment on other blogs, I usually do so under my initials, CAS, and leave the link to my blog when that feature is offered. In this way, internet searches of my name lead only to my work, but I am still held accountable for what I write online.

Thanks again for your interest. I look forward to what my colleagues have to say on this topic.

Cross-post from NF Endurance Team blog: Why Gabe Will Always Be My NF Hero

It’s a rare photo in which Gabe appears depressed. He was known for his boisterous, charismatic personality. But, from the time he left home for college, he struggled with depression. This photo was taken at my husband’s graduation from a pastoral training program in June 2004. Gabe would have just finished his freshman year at Wheaton College in Illinois.

I write about his depression because, as Endurance Team members, we are focused on overcoming and suicide seems like the antithesis of that. One thing I’d really like to accomplish through my involvement with the team is to help others overcome faulty ideas about depression and suicide. Ideas that I myself once held.

Not long before Gabriel died, I joined the CTF group on Facebook. A young woman posted a comment on the group wall about studies linking NF to psychiatric difficulties. I didn’t think much about it until after Gabe died. Then I began doing research and found one of the studies she may have been referring to. Here it is from PubMed:

Neurofibromatosis type 1 (NF1) is often associated with psychiatric disorders, which are more frequent in NF1 than in general population (33% of patients). Dysthymia is the most frequent diagnosis (21% of patients). There is also a high prevalence of depressive mood (7%), anxiety (1-6%), and personality (3%) disorders. The risk of suicide is four times greater than in the general population. Bipolar mood disorders or schizophrenia appear to be rare. The impaired quality of life associated with NF1 may play an important role in the development of psychiatric disorders. Quality of life assessments may help to identify a population at high risk.

Dysthymia can be defined as depression; despondency or a tendency to be despondent. It certainly describes Gabe at increasingly frequent intervals in the last year of his life. In another study, researchers found no link between the severity of familiar NF symptoms and the severity of psychiatric ones, indicating that something neurological might be going on rather than simple despair over the condition itself.

Since 2002, I have written for a magazine called Christianity Today. One of my articles was about Gabe and a couple others mentioned him. Because I had encountered a good deal of both ignorance and empathy after his suicide, I wrote about his death for the magazine. You can read that article here. It traces a bit of family history, does some education and poses the possibility that Gabe was suffering from bipolar disorder, which a couple of mental health professionals suggested after reading his suicide notes and journal entries. I’m ambivalent about this post-mortem analysis though, because the impulsivity that correlates with his attention deficit disorder combined with his undiagnosed dysthymia could be mistaken for bipolar.

Long before I had a thought about any of this, I wrote about Gabe’s NF in Christianity Today. That article was an investigation into human embryonic stem cell (hESC) research. Through it, I met my friend and NF Endurance Team partner David Brick. David is an hESC researcher at Children’s Hospital of Orange County, CA. When we were training for the Long Beach Half Marathon last year, David did some reading of his own on NF. He found something about the involvement of mast cells in NF. Mast cells are also indicated in asthma and allergies. This got me wondering if Gabe’s severe asthma might also have been a function of his NF. Instead of suffering from three separate diseases—NF, asthma and depression—was he really only suffering symptoms of one nasty disorder? I’d like to know the answer to this question.

The point of my writing about this here is both to alert CTF to these possibilities and to say that Gabe was for all of his life a true NF Hero. He overcame challenges that many of us will never face. The father from whom he inherited neurofibromatosis never acknowledged him and chose not to be a part of his life. He dealt with race issues as well, and was frequently sick and isolated with asthma. NF was always in the background as a concern. And yet, Gabe was incredibly accomplished. You can read about his many accomplishments here.

In one of his suicide notes, he wrote that as much as he kept trying to “pull himself up into the world of real people,” he felt dead inside. That feeling is not failure or a lack of courage; it’s a symptom of clinical depression. A symptom that he did not recognize had a treatment. A symptom he hid well in his lifelong habit of being an overcomer. A symptom I did not understand.

For the sake of others suffering such symptoms, I want to challenge the NF Endurance Team and its members to recognize that our message shouldn’t exclude those suffering from mental illness. Death by suicide is a preventable tragedy, not a lack of character. While we want to be careful not to romanticize or idealize those who die by suicide, we also want to remember that the vast majority of people who take their own lives die from mental illness that is no fault of their own.

So, here’s to my NF Hero, Gabriel Gifford Scheller!

Update: The NYC Half Marathon is just 10 days away and I’ve only raised $350 of my $1000 goal. If you’d like to help me answer the question posed in this post, you can support my efforts here, or you can send a check to: The Children’s Tumor Foundation 95 Pine Street, 16th Floor, New York, N.Y. 10005.

Beauty By Any Means Necessary

My latest post is up at Her.Meneutics. It’s called “Is it a sin to nip and tuck?” and was reclaimed from an article I worked on in 2007 that never made it to print. I offer the original here because my sources* made many points worth considering and because I think it’s a really good piece of work.

The photo above is of my sister Connie Smith before cosmetic surgeons created fingers for her from skin on her thigh. Connie was interviewed for this article. Living in Orange County, California, inspired my interest in the topic; Connie’s embodied experience informed my thinking.

“Beauty often wins love. It just does,” write Karen Lee-Thorp and Cynthia Hicks in Why Beauty Matters. No wonder women, and, increasingly, men are willing to endure the pain and risk of elective cosmetic surgery to attain it. New York Times reporter Alex Kaczynski states it bluntly in her cosmetic surgery expose’ Beauty Junkies. “In the end it all comes down to sex. … We are looking for love. And we will accept lust.”

Few admit this with the aplomb of Cena Rasmussen. This former model readily confesses that her cosmetic surgery addiction was fueled primarily by the bliss of turning heads. By her own admission, Rasmussen has spent years looking in the mirror. More often than not, she has seen reason to improve the image that stares back at her. Rasmussen was twenty-seven years old when Palm Springs, CA, cosmetic surgeon Razi Mazaheri first sculpted her flesh. He was dating Rasmussen’s friend and she was envious of the friend’s evolving, surgically-enhanced appearance.

In one transformative day, Rasmussen had breast augmentation, rhinoplasty, cheek implants and an eye lift. The breast augmentation didn’t heal properly and had to be redone almost immediately. In fact, one-quarter to one-third of breast augmentations will require additional surgery, according to Kaczynski and the FDA.

For Rasmussen, aesthetic surgery would become a biannual ritual that continued for two decades. There were more rhinoplasties, breast surgeries and lifts—eyes, face, neck—and non-surgical procedures as well. The regimen ended with a hyalauronic acid peel in 1999 that burned the skin on her face so badly, she says it left her looking like a “freak of nature.” Since then, Rasmussen has sworn off Mazaheri and has had nothing but $4000 worth of laser treatments to reduce the scarring. Still, she remains undaunted and is planning another face lift—her third, or is it the fourth? She can’t recall.

Racing into the Future

Rasmussen may represent an extreme in the use, or what some might call abuse, of cosmetic surgery, but the trend has been growing exponentially. In 2006, according to the American Society for Aesthetic Plastic Surgeons, Americans spent just under $12.2 billion on 11.5 million surgical and non-surgical procedures.

That’s a 446 percent increase from 1997. Surgical procedures increased by 98 percent and non-surgical procedures by 747 percent. Liposuction, breast augmentation, eyelid surgery, abdominoplasty and breast reduction were the top surgical procedures in 2006, while Botox injections, hyalauronic acid, laser hair removal, microdermabrasion and laser skin resurfacing were the most popular non-surgical techniques.

Ninety-two percent of patients were women, but men had nearly one million procedures. Forty-seven percent of patients were aged 35-50, 22 percent were 19-34, and 25 percent were aged 51-64. Ethnic minorities made up 22 percent of the patient pool.

Sculpting flesh is just the latest in millennia of questionable beauty-enhancement practices. The use of mobile x-ray machines for hair removal early in the last century is another. By the 1930s, the technique seemed “firmly entrenched,” writes Teresa Riordin in Inventing Beauty. She says women appear to have been “either ignorant of the dangers or simply willing to ignore them, given the ease and effectiveness of the treatment.” Sound familiar?

According to Riordin, women have long been collaborators and profiteers in this business. From the mid-nineteenth to the mid-twentieth century, for example, women received one-third of all U.S. patents, but in the category of pre-surgical breast enhancement (“falsies”), nearly two-thirds of patent-holders were women.

So what is a Christian to think about elective cosmetic surgery? Is it a sin to get a nip and tuck? Depends on whom one asks. I asked a variety of professionals and lay people. Their answers are an eclectic brew.

Choice

Lilian Calles Barger, author of Eve’s Revenge, says the choice to have cosmetic surgery is not a free one. “If you tell me, ‘my mother had cosmetic surgery. She’s a very independent woman. She really loves God and she wants to do this, and this is her choice,’ I say, ‘This is not a free choice. This choice is under duress.” Barger describes the phenomena as “appalling,” “gut wrenching,” “fundamentally wrong,” “a failure of the imagination.”

“The body is not just a hunk of meat,” she insists. “The body is significant in Christianity. The Bible talks about how we are to offer our bodies as living sacrifices to God. The question is what are we offering our bodies up to when we do that?” Her conclusion is that we’re offering them up to “false beauty and to cultural norms that we should be challenging,” but adds, “so that is where you can be compassionate, because you can understand that sin is not the sinner by themselves. It is collaborative, communal, reinforced. We support each other in this.”

Barger’s claim was born out in interviews with several cosmetic surgery patients.  In nearly every interview, individual choice was held out as a trump card, but all the women made their decisions within the context of relationships both personal and professional.

Therapeutic and Spiritual Perspectives

A disconnect between body and Spirit emerged in the reasoning of two patients who said body sculpting decisions are spiritually insignificant. “I don’t think it is a spiritual issue in any way,” says Rasmussen. “I personally believe that when we die, we’re going to have a glorified body that’s not going to be physical in any way. So what does the Lord care what we do to our skin?” Rasmussen explains that she both saved for her procedures and tithed faithfully throughout the exercise of her habit.

A fifty-something patient who asked not to be identified has had eye lid surgery, a chin implant, a mini-face lift and Botox. She says that as she struggled with the idea of tampering with the body God gave her, she sensed Him saying, “My beloved, you’re beautiful. You don’t need to do this.” She doesn’t believe, however, that tuning out the voice of God was sin. What matters, according to this patient, is “where your heart is.”

Cissy Brady-Rogers is a Pasadena therapist who has had a mastectomy, but no reconstruction after breast cancer years ago. She says that our culture “sets women up to feel shame about our bodies.” Body shame originates at home where children are not taught what to do with developing bodies and sexual impulses. It is then reinforced in school and through the larger culture. This coincides with what Brady-Rogers calls “disembodiment”—the phenomenon by which a subject looks into the mirror and sees that he or she does not measure up to cultural ideals and then comes to view their body as an object in need of repair rather than simply “me.” She says those considering aesthetic surgery would do well to heal the cause of their discontent (shame) rather than treating symptoms surgically.

Sociologist Philip Rieff talked about this disembodiment as “the triumph of the therapeutic” in his landmark 1960s book of the same name. It is a view of self as patient to be cured that he believed had replaced religion as the defining cultural narrative. He wrote, “That a sense of well-being has become the end, rather than a by-product of striving after some superior communal end, announced a fundamental change in focus in the entire cast of our culture—toward a human condition about which there will be nothing further to say in terms of the old style of despair and hope.”

For Christians walking out faithful body stewardship in defiance of this fundamental change, Brady-Rogers (who holds a Master of Divinity degree along with her other credentials) offers another narrative. She says patient-consumers are trying to figure out how to save themselves, just like the Galatians were, and in the process are biting and devouring one another by increasing the social pressure on all of us to conform to false ideals. “There is always going to be some law, some culturally offered avenue to save ourselves, to make ourselves okay, to fix what’s not working.” What Paul said is that it’s not going to work. Christ is the only one who can save us. “We are free to have plastic surgery. There is not a biblical law that says, ‘Thou shalt not have plastic surgery or drive a BMW,’ but what the Scripture says is: do not use your freedom as an opportunity for self-indulgence, but through love serve one another.”

For a woman contemplating aesthetic surgery, she advises, “I would like her to have a group of soul sisters who could support one another in becoming who they are in Christ, and support her in a process of discernment about that decision, not as solo journey. That may be part of the problem; too many women are making these decisions in isolation from other women.”

Idols and their Denouncing Prophets

Although the pursuit of beauty and the power it wields are timeless, a plethora of television makeover shows has normalized the triumph of both the therapeutic and the pornographic. Affluence and materialism, improved surgical techniques and doctors fleeing managed care realities for a cash business have all kept the engine humming along in the direction of more medical intervention to tame unwieldy flesh, according to Kaczynski.

In a 2004 New Atlantis article, “The Democratization of Beauty,” Christine Rosen wrote, “Cosmetic surgery … feeds our envy of those who embody nature’s most powerful but fleeting charms—youth, strength, beauty, and fertility. Its supporters praise its ability to change lives and its critics denounce it as the expression of our society’s worst impulses.”

As Christians reach for the charm, it’s these worst impulses that Hans Madueme, M.D., a fellow at the Center for Bioethics and Human Dignity, insist pose the greatest danger.

He calls the trend “deeply depressing” and says it’s one more area of American materialism that shocks his African family when they visit. The intuitive “yuk” reaction some Christians have towardaesthetic surgery is instructive, says Madueme. It tells us where the culture is moving, and reveals our loves, desires, idols and lusts. He suggests three “functional idols” that come into play with aesthetic surgery: youth, beauty and money. Consumers idolize youth and beauty, while medical providers exploit patients “inordinate desires” as a function of money idolatry.

Gary Churchill, a suburban Chicago facial plastic surgeon and aesthetic patient, offers a different perspective. He believes God directed him to a career that overwhelmingly consists of making women look and feel younger and more beautiful. Churchill was deeply offended when a fellow churchgoer suggested his work is incompatible with his faith. He takes a minimalist approach to surgery that leaves patients looking “refreshed” rather than altered.

Scot Rae, a bioethecist at Talbot School of Theology in La Mirada, CA, had an up-close and personal introduction to the world of cosmetic surgery when his wife Sally was having breast reconstruction after a double mastectomy. Although Rae was shocked to see young women in the surgeon’s office perusing catalogues that advertised buttocks implants, he strikes a middle ground.

Rae says Christians must see medical technology through a proper theological lense. He says God embedded his wisdom into creation through general revelation and that technology is “one of the primary ways that human beings unlock and apply God’s wisdom in the continuing quest to subdue the earth.” Rae allows that this quest was complicated after the fall, but says the three Ds—death, disease, and decay—were brought into the world by sin, and, as such, are legitimate targets for alleviation through technological means.

Like Madueme, Rae believes our intuitions are helpful, but sometimes in need of re-education. “They give us sort of yellow lights, but not necessarily red or green.” He offers a three-fold grid for evaluating aesthetic surgery. First, he says,” We are not our bodies, but we don’t devalue the body.” Second, “Medical technology, in general, to help alleviate the entrance of the effects of sin is a part of God’s common grace. And I think you can make a very good case that aging is a consequence of sin.” Third, “There’s a dynamic interaction between the soul and the body. So that’s why I think it makes sense that both men and women who have a change in their bodily appearance can feel better about themselves, and vice versa.” He concludes, “I think the bottom line is that you get principles and parameters out of Scripture and those form the fence around the field in which there’s freedom to make decisions.” If his eyelids were to droop in ten years, Rae says he would consider a nip and tuck.

Marketing toward Insecurity

To those who suggest that cosmetic surgery is marketed toward women’s insecurity, Ray Anderson, senior professor of theology and ministry at Fuller Theological Seminary in Pasadena, CA responds, “We need to look at it much more realistically, that it’s on a continuum. It’s on the same continuum as other aspects of embodied cultural life that effect our self-image….The solution to that [marketing towards women’s’ insecurity] is not to demonize an industry, but it is to revitalize the soul, the self in such a way that one is free to make use of products, services, opportunities within responsibility without having to be branded in ones own mind at least to be capitulating to that culture. We have to be strong enough so that Christian women now need to be socialized in the Christian community in such a way that they are able to make good choices with regard to products and opportunities to enhance their appearance and self-esteem within their culture.”

Anderson’s son-in-law Gregory Evans is chief of aesthetic and plastic surgery at UC Irvine Medical Center in Orange, CA. His practice is equally divided between corrective and aesthetic surgery. Evans says, “We all as physicians help people, but our area of the field is really trying to focus more on quality of life issues. … So one day a hand, another a cleft lip, breast reconstruction, injecting Botox around the eyelid—so we’re involved in the whole facet of a person.” Evans acknowledges the potential for exploitation, but offered a four page code of ethics from the American Society of Plastic Surgeons as evidence that his board is serious about combating unethical advertising practices fueled by greed.

The only board certifications Kaczynski trusts are those offered by the American Board of Plastic Surgery and the American Board of Medical Specialties.

Anne Brattli is an aesthetician and salon owner in Sarasota, Florida. Brattli found out the hard way that not all board certifications are equal. Ignorant of uneven licensing practices in the industry, she briefly went to work for Kurt Dangl, a practitioner who was later featured on 20/20 and in Beauty Junkies for his part in the death of a breast augmentation patient whose anesthesia was administered by an unlicensed “nurse.”

Brattli says Dangl offered free surgeries to employees after four months of employment. At first she considered a tummy tuck or liposuction. But after witnessing the grisly realities of the operating room (which were visible from the break room where employees ate their lunch), Dangl’s arrogance and myriad grotesque complications, she changed her mind. Eventually she learned that Dangl’s primary training had been in dentistry and took an early and permanent maternity leave.

Brattli has been examining women’s faces under a high-powered microscope for a decade. She identifies a nagging problem with medically enhanced beauty. “When you’re talking to someone who’s had Botox and they smile at you, they don’t look sincere and you can’t put a finger on it, but it’s because they’re smiling at you with their mouth and not with their eyes. When you get a person who smiles with their eyes and their mouth, you feel like they’re genuine. With Botox, it doesn’t matter if they’re genuine. It just never reaches their eyes.”

“Sooner or later a person that resorts to some artificial way of delaying aging or overcoming some perceived abnormality is going to have to deal with the fact that you’re going to have to live with what you’ve got,” concedes Anderson, who, at 80-years-old, is still dying his hair and beard dark brown.

Wisdom from Tarnished Humanity

Some women, like Connie Smith, never have had a choice about the bodies they inhabit. Smith was born with multiple birth defects [her term of choice]: congenital constricting bands that cut off most of her fingers at or below the knuckles, a clubbed foot and webbed toes. With sponsorship from March of Dimes, cosmetic surgeons created digits that have served her well for more than 40 years. Perhaps it is women like her, Brady-Rogers and Sally Rae who have the most to teach us about living within our imperfect, aging bodies.

Smith is a homemaker and is divorced from her husband. Facing the idea of mid-life dating and re-entry into the job market, she has no plans for medical enhancement. She feels the same cultural pressures that others do, but says when she feels good about other areas of her life—particularly her relationships with God, family and friends—her birth defects don’t bother her or others. “When I’m feeling good, I project an air of confidence, she says, “My hands are the last things on someone’s mind; they are looking at my face or my body, or they are listening to my words. My hands are irrelevant. When I project insecurity, I feel like some people treat me like I’m invisible. They’re looking at me in a different way.”

Transcendent Pursuit

Rieff and Kaczynski may be correct that the therapeutic and the pornographic have triumphed. The theologians may be correct that technology can be either used responsibly or abused in a Christian context as it alleviates the effects of the fall. Feminists and therapists may be correct that the industry exploits women’s greatest insecurities and culturally induced shame. But there’s also something uniquely American and Protestant in the wholesale rush to embrace medical enhancement.

David Brooks describes this strain of perfectionism in American life in his book On Paradise Drive. He writes, “Unlike some other bourgeois nations, we are also a transcendent nation infused with everyday utopianism,” a utopianism that “lures us beyond the prosaic world” and “gives us a distinct conception of time, so we often find ourselves on some technological frontier,” Of these ever-expanding frontiers, Brooks duly notes that we occasionally look back on them with regret.

As medically altered faces and bodies become more commonplace, will the era of Botox and DD breast implants be one we regret? Will the dangerous excesses be abandoned as x-ray hair removal machines were? One can only hope.

*Note: I have not updated the information in this piece. Source affiliations and cosmetic surgery stats may have changed.

Clarification on hESCs

Now that I’ve had a moment to breathe (and get some laundry into the washing machine), I thought I should clarify a couple conclusions from my final post on stem cell research. When I stated that human embryonic stem cells (hESCs) are not likely to be the “great therapeutic hope they have been pumped up to be,” I was not expressing my own best judgment from the 10 day NIH training course. This statement was based on collective scientific opinions and on one opinion in particular. The source has been a strong proponent of hESC research and a significant player in the field. There may be other uses for hESCs, but this expert says the carcinogenic/immunological combination creates an “insurmountable” obstacle to therapy.

When I said that the best hope for therapies lies with induced pluripotent stem cells (iPSCs) that originate in one’s own body, it may have sounded simplistic. This statement, however, also emanated from both collective wisdom and the expressed opinion of a respected “off-the-record” source.

When I said that adult stem cells from donor sources pose significant risks, I did not mean to suggest they are not useful for therapy. They are. A family member has benefited from them. A friend suffered miserably from the graph vs. host disease that is sometimes a side effect of such treatment. She was desperately ill with the cancer that eventually killed her when she was injected with stem cells from cord blood.

Medical researchers talk in terms of risk/benefit analysis. Obviously someone dying of a deadly disease doesn’t have much to lose if hESC therapies prove to be carcinogenic or if adult source therapies require ongoing immunosuppression. The quadriplegic or diabetic does.

Finally, I should note (for what little credibility it provides) that I did significant course work in anatomy, biology and chemistry before I settled on journalism as a college major.

Cheers to hESCs@CHOC

It’s been many, many years since I’ve sipped a cocktail like the one above, but this was the celebratory drink ordered for us by I don’t know whom on the last night of the NIH hESC training course. The tray of drinks reminded me of a plate of cell cultures so I snapped a photo. It was a fun evening and by the time it arrived, the scientists were generally at ease with this “religious woman.” I really liked them, as was the case last time I attended.

Two interesting conversations stuck with me from the final evening. First, a Brazilian woman asked me if I’m able to separate my personal beliefs about hESC research from my reporting. It’s a fair question, but one nobody asked of Gary Robbins … and he wasn’t shy about sharing his beliefs, religious or otherwise.

Every day of the week, journalists must set aside their personal convictions and report the news. Non-journalists sometimes think this doesn’t happen; they see bias everywhere. In fact, my first introduction to the notion of postmodernism came not from any discussion of pop-philosophy, but from the Walter Lippman classic Public Opinion. In it, one of the founding editors of The New Republic argued that we all see life through the limiting lens of culture and language. The best we can strive for is fairness. Read Lippman’s Wikipedia bio; it provides a compelling look at the interplay of democracy, philosophy and the news.

Gary reports differently about hESC research than I would, but not only because we have different beliefs about the ethics of this work. He is under daily news deadline pressure and I’m an occasional, long form writer with a bent for investigation. I look for what’s not being said or reported. In this case, what’s not being reported with any regularity or conviction in major news outlets is that hESCs are not likely to be the great therapeutic hope they have been pumped up to be.

This is not my opinion, but the somewhat reluctant opinion elicited from 10 prominent scientists who were asked some challenging questions at yesterday’s concluding symposium. The first question was: What are the long-term cancer risks of hESC therapies? Jeanne Loring, whose extensive credentials include work on the Human Genome Project and collaboration on the WARF patent challenge, did not let any of her peers off the hook as moderator of the Q&A. One by one the Oxford guy, the Stem Cell Inc. guy, the Stanford guy et. al. admitted that they have no idea and no answer for this concern.

That’s big news in and of itself, but not for this venue. …

The other significant conversation I had on our final evening together was with the scientist who asked me about The Secret. She did foundational work in the hESC field … as a born-again Christian. The work kept her out of church for ten years, until one day she was looking at hESCs differentiating into various cell types under her microscope. They reminded her of the human race in all its diverse beauty. She imagined God looking down upon humanity through his lens and desiring us to sing hymns and praise songs to him in unison (hESCs have a biological imperative to congregate). She decided it was time to go back to church.

This gracious Christian who was admired by everyone shared her story freely. However … however. She is still not entirely comfortable with her hESC work … and she won’t be telling her story on the record any time soon.

There is much, much more that can be said about the past ten days, but I came away from them with three strong convictions:

  1. Nearly as important as the ethics of hESC research is the lack of regulation in the IVF industry. The United States is far behind many European nations in its concern for 1) the well-being of women receiving IVF therapies, 2) children born of egg/sperm donation and multiple births, and 3) both the exploitation of egg donors and the fate of their eggs.
  2. The best hope for therapeutic uses of stem cells lies in iPSCs that originate in one’s own body. Not only do potential hESC therapies pose significant risks, but adult stem cell therapies from donor sources do as well. Arlene Chiu asked the representative from Stem Cell Inc. if the stem cells in their inaugural FDA-approved human trial had been tested for diseases like neurofibromatosis (NF). Chiu had heard a talk by an NF1 researcher who found that neural stem cells transplanted into a mouse brain resulted in a proliferation of NF tumors in the brain. The Stem Cell Inc. representative said that some screening had taken place, but it was not comprehensive. Chiu was incredulous.
  3. The hype over hESCs has done considerable harm. During the panel discussion, the eminent panelists were confronted by an Autism advocate who wanted to know what can be done about desperate parents taking their sick children outside the United States for non-FDA approved stem cell treatments. One MD commiserated with the woman’s experience, saying it mirrored his own; another panelist noted that a scientist who had investigated charges against a Chinese clinic had been subjected to an “investigative review” of his own by the scientist whose advertised results he found spurious. No suggestions were offered … nor was any responsibility taken for pumping hESC research up and selling it as THE great hope for all manner of human suffering.

UPDATE 3/19: Clarification on this post.

Winding Down

I’m on day 10 or so of conference lectures. Today it’s Stem Cell Culture Secrets and Patent Issues (which combine into quite the quagmire in the hESC field). Yesterday I only attended one talk, that of Gary Robbins, the Science Dude at the Orange County Register. Gary’s blog about local science news gets a lot of traffic. I picked up some good tips.

This week he is running two polls. One is about whether or not it will demean a trained elephant to temporarily encapsulate it in a giant bubble as part of a stunt at the Discovery Science Center (371 respondents said no; 353 said yes as of 6:42 am this morning). The other is called “Is Science Sinful?” It asks about a senior Catholic cleric’s declaration that certain types of scientific research (including genetic manipulation of human embryos) are sinful. This poll only got 68 responses: 43 disagreed with the cleric, 7 agreed and 18 said the question was too vague.

If these polls are to be taken seriously—and I’m not sure they are—more Orange County Register readers care about the temporary fate of a trained elephant than care about a prominent theologian’s opinion about what it means to be human.

Gary and I have emailed back and forth a couple times in regard to his coverage of local hESC news. It was good to meet him in person. He’s appropriately kinetic, and gave a current events talk about the impact of the Internet on the news business. He also handed each of us a dime to demonstrate how hESC scientists ought to talk to the press about their work. He said that when he talks to people about hESCs, he uses a dime to demonstrate that the 8-celled blastocysts destroyed in the research are the size of President Roosevelt’s eye on the coin. His was a lecture about educating a busy public about science rather than one about how hESC scientists can avoid being misquoted or manipulated by unscrupulous or untrained reporters.

After the lecture, I attended a party at the hotel where the students are staying. We sat together in a dark room on the 18th floor and watched the fireworks over Disney Land. I was asked my opinion of The Secret and will be researching that today for a lovely, accomplished scientist from another part of the world. She doesn’t want to buy into The Secret’s message if it is inconsistent with Christian faith.

I also heard last night that Hans Keirstead is being shadowed by an HBO film crew and that he’s toned down his rhetoric, which, if true, is good for everybody.

Tomorrow, the NIH course wraps with an all-day symposium on stem cell treatment for pediatric diseases. Then I’m off to Santa Cruz to meet a faithful blogging friend in person. While I’m there, I’m going to worship at Vintage Faith Church where my new friend Dan Kimball pastors. After that, I’ll be spoiling my family for a bit and getting down to some serious writing work.

Update: I was thinking more about Gary’s polls. There are other possibilities for the divergent interest. First, Gary said his readers respond more to local science news than national or international news. Second, perhaps readers rightly discern that the temporary fate of a trained elephant is trivial enough for a 2-second opinion poll, whereas contemplating what it means to be human requires a bit more thought.

Update 2 (3/15/08): The Bubble/Elephant stunt at the Discovery Science Center has been canceled after an outpouring of public protest.

Monday Notes on hESCs@CHOC

 

 

Michael Kalichman, director of the Research Ethics Program at UC San Diego, spoke this morning about hESC ethics. His was a probing Q&A format as he tried to get the scientists to think through the pertinent issues. They didn’t say much, but I believe his questions got them thinking. The discussion wasn’t really an “Is hESC research right or wrong?” discussion, but one about reasoning out inconsistencies in logic. It was a fair discussion, except that he said the opposition equates leftover IVF embryos with live children. I’m not sure that’s accurate. Of more concern to me than the fate of a finite number of leftover IVF embryos is who we become as a society if we don’t do the hard work of thoroughly hashing out the ethics. This is where religious voices are vital to the discussion. Unlike Sidney Golub who said he doesn’t like slippery slope arguments, Kalichman gave weight to concerns about where hESC research might lead. I think it is fair to say that proponents invoke their own brand of slippery slopism when they resist all constraints, regulations and/or oversight.

I won’t say much more about Kalichman’s lecture here, except that the ethics discussion once again appears to have progressed in both tone and content. Early in the talk, he warned that what happened in Korea could happen here and he advised the budding hESC researchers to abide by whatever rules govern their work.

Three important points:

  1. In light of advances with iPSCs (induced pluripotent [adult] stem cells), he thinks it is not unreasonable for ethics committees to require that research proposals include a defense of the use of hESCs over iPSCs.
  2. It is too early to conclude that hESCs and iPSCs will be therapeutically interchangable; therefore all types of stem cell research should proceed.
  3. As a proponent of hESC research, he advised students to treat human embryos with respect because they are more than ordinary cells.

A discussion comparing the ethical constraints on hESC researchers to those on journalists ensued. It was kind of funny, as I realized that journalists may be less popular than hESC researchers. Many hESC researchers are interested in curing disease after all … as are many journalists, only our work is focused on curing (or, at least exposing for treatment) societal ills rather than physical ones.

Kalichman mentioned something about journalists not identifying themselves appropriately. This got me thinking more about blogging conferences. I don’t believe it is my responsibility to tell each lecturer at a public or semi-public event that I will be blogging their session from a particular point of view. They should assume that a lecture (especially one sponsored by the National Institutes of Health) delivered to an undefined audience is fair game to be reported on. As a courtesy, a conference host might wish to alert speakers to the presence of media, but I don’t believe it is required of them either. Additionally, in this situation, I introduced myself to the students as a journalist on day one. I have not named any of them, and will not in this or any other venue without their permission. If I request any formal interviews, only then will I discuss with sources the parameters and possible consequences of an interview.

Two side notes:

  1. This morning, I also attended a lecture on Aneuploidies (chromosomal abnormalities) in hESC culture. The significant development from 3 years ago is that there appear to be two types of aneuploidy: one potentially carcinogenic and one that may be a normal and harmless feature of stem cell culture.
  2. Speaking of new developments, I heard on Friday that Hans Keirstead’s technique for culturing highly undifferentiated oligodendrocytes has been replicated. I’ll have to check into it.
[photo hESC cultures, ©cas 2008, Orange, CA]

Friday Fun with Religion, Science and the Press

Friday, March 7, 2008

ACT I:

12:00 pm, directly after a Psychiatry & Spirituality Forum lecture to psychiatric residents at UC Irvine

(Paraphrasing)

Senior Staff Doctor: “Hello”

Christine: “Hi, I’m Christine. I’m a journalist. I’m doing a story on the Forum for xyz news outlet.

Senior Staff Doctor: “Every time I talk to a reporter, I come out sounding like an idiot. …”

Christine: “Sometimes it’s not the reporter’s fault. It’s those word counts. You have to talk in sound bites.”

Dr. Kheriaty agrees, kibitzing follows.

Senior Staff Doctor to Dr. Kheriaty: “That reporter from wxt news outlet called. She wanted to know if you are some kind of religious zealot. I told her you aren’t, but you know, you ought to have my Native American friend speak. He really helped us get through a contentious work situation.”

Dr. Kheriaty: “We try to be imperically-based and inclusive …”

ACT II:

5:45 pm, CHOC Boardroom, before NIH Embryonic Stem Cell Training Course students arrive for lecture and dinner

(paraphrasing)

Renowned Stem Cell Researcher: “Hello”

Christine: “Hello”

Renowned Stem Cell Researcher: “Are you a student?”

Christine: “No, I’m a journalist.”
Renowned Stem Cell Researcher: “A journalist? From what publication?”

Christine: “I’m pitching a story to xyz news outlet. It’s non-sectarian.”

Renowned Stem Cell Researcher: “It’s not Catholic is it?”
Christine: “No, but I’ve written from that perspective before. I’m not doing that this time. People should be able to disagree and still be respectful though, don’t you think?”

Renowned Stem Cell Researcher: “I don’t know. I’m glad I asked.”

Christine: “Why, will you say something different in your lecture because I’m here?”

Renowned Stem Cell Researcher (direct quote): “No, but the Catholics. I’ll be honest. I despise them.”

Christine: stunned silence

Renowned Stem Cell Researcher (paraphrasing): “The bishop of tzv came down to mwl saying he’s against IVF, ruining a lot of people’s happiness.”

Christine (to herself): “Nice to meet you too.”

[photo ©cas 2008, CHOC North Boardroom, Orange, CA ]

hESCs@CHOC 2

Day 2 of the NIH hESC Training Course was fascinating. This year, I’m not hanging with the scientists 10 hours-a-day, but am only attending lectures that might address advances or new challenges in the field. Once again, I’m struck by the chastened tone, not only of the students, but of the speakers. Phil Schwartz set the tone on day one when he showed a series of slides spanning the gestation of a human fetus from embryo to birth.

In the morning, Dr. Thom Nass from Coastal Fertility Medical Center spoke about invitro fertilization (IVF). The reason for Dr. Nass’ talk is that hESC lines are generated from leftover IVF embryos. Some things I learned or relearned about IVF:

  • The United States is the “Wild West” when it comes to IVF regulation, and even some professionals aren’t happy with this reality. Dr. Nass, who used the phrase Wild West to describe the situation, would prefer more regulation so that he and his colleagues are not left entirely on their own in advising patients about these complex issues. In contrast, a cell biologist from Estonia would prefer less regulation in his country. Potential egg donors there must be approved by multiple committees before they give up their eggs.
  • This is probably not a bad thing, as the potential for exploitation is integral to this transaction. Nass said egg donors are paid $5000-$6000 per cycle, which includes 5-6 weeks of chemical manipulation of their pituitary function. I can’t recall the colorful analogy he made to the extreme version of PMS that women experience with treatment, but the point is that chemically manipulated hormones are no picnic for patients or their families. Some women’s eggs are worth more than others. In Irvine, CA, where Nass practices, there is a large Asian population and he says Asians are much less likely to donate their eggs than other ethnic groups. Thus, Asian women can earn up to $50,000 selling their eggs. A UCLA MD/PhD confirmed this statement.
  • Preimplantation Genetic Diagnosis (PGD) is now standard for sifting out defective embryos. The procedure involves puncturing the embryo and removing a single cell for screening. Nass says concerns about damage to the fetus from this procedure have been found to be without merit. hESC lines theoretically can be generated from this single cell once genetic testing is completed (thus creating yet another non-embryo destroying source of hESCs). I’m unsure if scientists have already done this.
  • Coastal Fertility Medical Center does not do PGD for sex selection, but sex selection is legal in the United States and other labs are willing to do it.
  • Until last year HIV patients could not legally have IVF embryos implanted in California. Nass says disease transfer is not a significant problem. He thought the Americans with Disabilities Act might have contributed to the change in law.
  • Egg freezing techniques continue to improve, but freezing eggs is still a secondary option to embryo freezing at US IVF clinics. In Europe, where restrictions on creating embryos exist are stricter, egg freezing is more common.
  • The vast majority of IVF patients are not interested in donating extra embryos through adoption services like Snowflakes. Nass says this is because most couples don’t want a bunch of their genetic progeny running around out there in the world. I reminded him that this is exactly the reality for egg donors (and sperm donors, for that matter).

In the afternoon, I returned to CHOC to hear Dr. Sidney Golub talk about Stem Cell Policy and Politics. Last time, Dr. Golub’s talk sparked a debate between me and a number of others that ended with one of the instructors in tears, but advising me to continue engaging the issue. I determined to avoid a repeat yesterday. Golub made it easy to do with his more even-handed presentation. (I confirmed this impression with someone who had been present for the other talk.)

I surmise four possible reasons for the change:

  1. The Korean somatic cell nuclear transfer (cloning) scandal seems to have softened some of the gung-ho cowboy bravado.
  2. The proven feasibility of creating induced pluripotent stem cells (iPSCs) from adult stem cells.
  3. The embarrassing nature of a particular hESC scientist’s rhetoric.
  4. The strength of opponents’ argument that it is simply wrong to kill and experiment on destroy human embryos for experimentation. This one is not a guess. Golub conceded, with humilty, that this moral claim is a powerful one.

Dr. Golub did not look well, an observation I was not alone in making. I hope he takes care of himself, because he seems to have become a voice of reason in the debate. Here are some noteworthy points:

  • He prefers peer review and regulation to legislation, even, I believe, in regard to California’s controversial Prop 71, which he says New York copied nearly verbatim. He outlined a historical precedent for this approach.
  • England’s system of regulation is a good model; it separates science from political arguments.
  • Various Scientific organizations have come to a consensus on several points:
    • local oversight is preferable to national oversight
    • provenance of cells and tissues (don’t recall what this refers to)
    • altruistic donations of genetic materials (women can sell their eggs to make babies, but not for experimentation)
    • no reproductive cloning or reproducing chimeras
    • new cell lines will be necessary due to genetic instability
    • a national advisory group should be established (this really hasn’t happened, according to Golub)
  • Former chairman of the President’s Council on Bioethics, Leon Kass, was “controversial, extravagently bright, unafraid to make enemies.” In contrast, the current chairman, Edmund D. Pellegrino, is widely respected and a devout Catholic. Kass’ council appeared politicized in part because of the removal of two highly qualified hESC advocates, Dr. Elizabeth Blackburn and Dr. William May.
  • According to Golub, patient groups are still the primary proponents of hESC research, though public support runs in the 60% range. The Juvenile Diabetes Research Foundation speaks with the “strongest voice.” Notably, the pharmaceutical lobby has been silent on the issue.
  • Nearly everyone (80-90% of the population) is opposed to reproductive cloning. It is “dangerous and likely to fail.” Therapeutic cloning (SCNT) is another story. Golub supports it for research purposes, but thinks it is highly unlikely to be useful for therapies.
  • Take home lessons: 1.) stem cell policy doesn’t easily accomodate compromise, 2.) legislation struggles to keep pace with science, 3.) US policy is a patchwork of limited federal programs and conflicting state policies + private enterprise, 4.) there is consensus on constitutional oversight, 4.) US science policy from 1945-2000 focused on priorities to be funded in contrast to the current interventionist approach.

During the Q&A, a San Diego cell biologist told the story of going to a Tijuana stem cell clinic with a reporter from the San Diego Union Tribune and described a heartbreaking scene of suffering families being sold a bill of goods in a glossy presentation.

Last evening at dinner, the scientist I mentioned in my previous post asked what “that religious woman” was doing at the course. My presence was once again defended by the host who invited me. In coming days I hope to convince her that I am a person, and not just “that religious woman.” I also hope being viewed as such doesn’t wear me out to the degree it did last time.

hESCs@CHOC

I’ve gone straight from engaging with pastors to engaging with post-doctoral scientists. What, you ask, do I mean? Well, for the next 10 days, I’ll be at Childrens Hospital of Orange County (CHOC) attending the 5th annual NIH Human Embryonic Stem Cell (hESC) Training Course. I attended three years ago and already noted a significant development. Two of the dozen scientists in attendance are here to learn how to culture hESCs so that they can reprogram adult stem cells into the more versatile pluripotent ones, not because they want to be hESC researchers.

Phil Schwartz was prescient when he stood by his convictions to work with the NIH approved cell lines in the belief that alternatives to destroying new embryos would emerge. He named at least three alternatives this morning: stem cells derived from adult cells, from eggs and from sperm. Of course, I’m not yet sure how interested the students are in all that. Phil will make sure they get a well-rounded introduction to the field. For this tax-payers can be grateful.

I won’t be blogging much from this material, as I’m working on stories for other outlets, but I will try to reserve something for Exploring Intersections. A few of the lecture topics I’m particularly interested in are as follows:
  • IVF
  • Anuploidies
  • Ethics
  • Talking to the Media
  • Stem Cell Patents
  • hESC Culture Secrets
  • Stem Cell Transplantation

Three years ago I met one of my closest California friends through this course. That friend is now a NIH-funded hESC researcher. This morning, when I told a student that I had just come from a pastors conference, she remarked that the two groups were polar opposites. And isn’t that part of our problem? Not only is there a misconception that science and religion must be at odds, but there is also a prevailing wind of public discourse that always frames the “other” as an enemy. I hope to do my little bit to change the direction of the wind. We’ll see. First I’ll have to get past 30 minutes of Sidney Golub talking hESC politics from what I expect to be a calcified point of view.

2008 NIH-sponsored HESC Course

I’ll once again be attending this year’s NIH course at CHOC. For scientists interested in all types of stem cell research, here are the details:

The following information is for the NIH-sponsored Human Embryonic Stem
Cell
Culture Training Course to be held at the Children’s Hospital of
Orange County (CHOC), in Orange, California, March 4-13, 2008. Please
post/forward to all interested colleagues, staff, and students.

This Human Embryonic Stem Cell Culture Training Course brings together
some of the leading experts on embryonic stem cell technology, and
through comparative approaches, train students in the successful culture,
maintenance, and manipulation of embryonic stem cells.

The on-line application can be found on the National Human Neural Stem
Cell Resource web site – www.nhnscr.org – simply by following the link
on the left side-bar.  A full description of the course as well as the
faculty and facilities can also be found on this site.

The tuition for the course has been set at $1,500. This covers all
supplies and materials for the course.  There are additional costs for
meals, housing, and transportation between the hotel and the teaching
facility and these will be described in the registrations materials sent to
accepted applicants. It is expected that these costs will range between
$2,250 and $3,000, depending negotiated rates. In addition, students
are responsible for travel costs between the hotel and their homes/home
institutions.

The on-line application deadline is January 11, 2008, but applications
submitted after that time will be considered if space is still
available.

Prospective students will be notified of their acceptance/rejection
after January 18, 2008.  There is room for 12 students for this course.
  Prospective students should also indicate in an accompanying e-mail if
they wish to be considered for the next course.

Full tuition deposits for accepted students are due by February 8,
2008.

Please note the following:

1) Limited scholarship support is available for under-represented
minorities who meet US citizenship requirements. To apply, contact the
course director.

2) Applicants need not be Principal Investigators or Program Directors
but, if not, the applicant must provide written confirmation from their
Principal Investigator or Program Director that they will use the
skills that they have learned at the course upon return to their home
laboratory.

3) Applicants (or their Principal Investigators or Program Directors)
must provide written evidence that they already have human embryonic
stem cells
or written evidence of intent to procure human embryonic stem
cells
.